Pre-B cells; normal and abnormal development.

The immediate precursors of B lymphocytes have been recently identified in fetal liver and in bone marrow. Immunoglobulin genes, first of the heavy-chain gene family and later from one of the light-chain gene families, are selected and undergo functional rearrangements on one of each chromosomal pair during this stage of differentiation. Thus clonal diversity is generated among cycling pre-B cells that lack the surface antibody expression which characterizes their B-cell progeny. While the number of discriminating markers for pre-B cells is still limited, examination of bone marrow pre-B cells containing cytoplasmic mu chains but lacking surface immunoglobulin has already revealed an informative spectrum of early differentiation defects in antibody deficiency diseases and malignancies of B lineage.
AuthorsM D Cooper
JournalJournal of clinical immunology (J Clin Immunol) Vol. 1 Issue 2 Pg. 81-9 (Apr 1981) ISSN: 0271-9142 [Print] UNITED STATES
PMID6801081 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Antigens, Ly
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Light Chains
  • Receptors, Antigen, B-Cell
  • Animals
  • Antigens, Ly (immunology)
  • B-Lymphocytes (cytology, pathology)
  • Birds
  • Bone Marrow Cells
  • Cell Differentiation
  • Cell Transformation, Neoplastic (pathology)
  • Female
  • Fetus (cytology)
  • Humans
  • Immunoglobulin Heavy Chains (genetics)
  • Immunoglobulin Light Chains (genetics)
  • Immunologic Deficiency Syndromes (immunology, pathology)
  • Kinetics
  • Leukemia, Experimental (immunology, pathology)
  • Leukemia, Lymphoid (immunology, pathology)
  • Liver (cytology)
  • Mice
  • Mice, Inbred Strains
  • Pregnancy
  • Rabbits
  • Receptors, Antigen, B-Cell (immunology)

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