[Effects of anti-inflammatory drugs on the arachidonic acid induced erythema in guinea pigs (author's transl)].

Abstract

The inhibitory effects of anti-inflammatory drugs on th erythema induced by arachidonic acid in guinea pigs were studied. Values of ED50 (mg/kg, p.o.) were; diclofenac sodium (19.9), indomethacin (28.1), naproxen (52.4), phenylbutazone (67.1), ibuprofen (81.3), aspirin (92.6). These drugs, however, were ineffective on the erythema induced by prostaglandin E2. Basic nonsteroidal and steroidal anti-inflammatory drugs and anti-oxidants were negative in the inhibition of arachidonic acid-induced erythema. Cyproheptadine as an anti-histamine and -serotonin agent and morphine as a CNS acting agent were also negative. Erythema did not occur following treatment with linoleic acid, linolenic acid and gamma-linolenic acid. Bishomo-gamma-linolenic acid-induced erythema was inhibited by diclofenac sodium. The inhibition of acidic nonsteroidal anti-inflammatory drugs in this system seemed to be the result of a block of the enzymatic conversion of arachidonic acid to prostaglandins. The arachidonic acid-induced erythema in guinea pigs can serve as a new animal model for evaluating prostaglandins biosynthesis inhibitors such as anti-inflammatory drugs.

• Authors: S Otomo, S Higuchi, M Tanaka, Y Gotoh, Y Osada, M Ohzeki
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 78 Issue 3 Pg. 185-90 (Sep 1981) ISSN: 0015-5691 [Print] Japan
• PMID: 6799367 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Arachidonic Acids
• Prostaglandins
• Prostaglandins E
• Arachidonic Acid
• Dinoprostone

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Arachidonic Acid
• Arachidonic Acids (metabolism)
• Dinoprostone
• Disease Models, Animal
• Erythema (chemically induced)
• Guinea Pigs
• Male
• Prostaglandins (biosynthesis)
• Prostaglandins E