Megakaryocytic leukemia; identification utilizing anti-factor VIII immunoperoxidase.

Abstract

Coagulation Factor VIII is produced by endothelial cells and megakaryocytes. Antibody directed against Factor VIII or its associated antigens has been shown to be a sensitive marker for both normal and neoplastic endothelial cells. Its use to identify neoplastic megakaryocytes has not been described. We used immunoperoxidase localization of Factor VIII to identify megakaryocytes and immature megakaryocytic precursors in a case of megakaryocytic leukemia.

• Authors: D J Innes Jr, S E Mills, G K Walker
• Journal: American journal of clinical pathology (Am J Clin Pathol) Vol. 77 Issue 1 Pg. 107-10 (Jan 1982) ISSN: 0002-9173 [Print] England
• PMID: 6798857 (Publication Type: Case Reports, Journal Article)

Chemical References

• Factor VIII

Topics

• Aged
• Bone Marrow (pathology)
• Factor VIII (analysis)
• Female
• Humans
• Immunoenzyme Techniques
• Megakaryocytes (analysis, pathology)
• Thrombocythemia, Essential (immunology, pathology)