Teleocidin, lyngbyatoxin A and their hydrogenated derivatives, possible tumor promoters, induce terminal differentiation in HL-60 cells.

Abstract

Teleocidin isolated from Streptomyces mediocidicus, its catalytically hydrogenated compound dihydroteleocidin B, and lyngbyatoxin A isolated from marine blue-green alga Lyngbya majuscula as well as its hydrogenated product, tetrahydrolyngbyatoxin A were tested for their ability to induce differentiation of human promyelocytic leukemia cells (HL-60 cells) in culture. All of these indole alkaloids induced differentiation of HL-60 cells, characterized by increased phagocytosis, increased release of lysozyme, and morphological changes resembling macrophages. The concentrations required for the induction were 1-5 ng/ml, showing similarity to those of 12-O-tetradecanoylphorbol-13-acetate (TPA). Teleocidin, lyngbyatoxin A, and tetrahydrolyngbyatoxin A are suggested to be tumor promoters, like TPA and dihydroteleocidin B. The HL-60 cell system might be useful for screening for environmental tumor promoters.

• Authors: M Nakayasu, H Fujiki, M Mori, T Sugimura, R E Moore
• Journal: Cancer letters (Cancer Lett) Vol. 12 Issue 4 Pg. 271-7 (May 1981) ISSN: 0304-3835 [Print] Ireland
• PMID: 6796252 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Alkaloids
• Carcinogens
• Dermotoxins
• Lyngbya Toxins
• teleocidins
• dihydroteleocidin B
• lyngbyatoxin A

Topics

• Alkaloids (toxicity)
• Carcinogens (toxicity)
• Cell Transformation, Neoplastic (drug effects)
• Dermotoxins (toxicity)
• Humans
• Leukemia, Myeloid, Acute (pathology)
• Lyngbya Toxins