Antiprostaglandin synthetase activity of nonsteroidal anti-inflammatory drugs and gastrointestinal micro-bleeding: a comparison of flurbiprofen with benoxaprofen.

Abstract	By using 51Cr-labelled erythrocytes and 141Ce-labelled microspheres to correct for daily variations in faecal output, gastrointestinal microbleeding was measured in hospital patients with rheumatoid arthritis before and after administration of 2 propionic acid derivatives. These were flurbiprofen and benoxaprofen, respectively a potent and a weak prostaglandin synthetase inhibitor. Increased faecal blood loss occurred consistently with flurbiprofen and not with benoxaprofen. Our results provide indirect evidence for the cytoprotective effect of prostaglandins on the gastrointestinal mucosa in man. The quantitative correlation between faecal occult blood loss as measured by the above techniques and the Haemoccult slide test is also discussed.
Authors	A C Yeung Laiwah, T E Hilditch, P W Horton, J A Hunter
Journal	Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 40 Issue 5 Pg. 455-61 (Oct 1981) ISSN: 0003-4967 [Print] England
PMID	6796008 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anti-Inflammatory Agents Benzoxazoles Cyclooxygenase Inhibitors Propionates benoxaprofen Flurbiprofen
Topics	Aged Anti-Inflammatory Agents (adverse effects) Arthritis, Rheumatoid (drug therapy) Benzoxazoles (adverse effects) Cyclooxygenase Inhibitors Feces Female Flurbiprofen (adverse effects) Gastrointestinal Hemorrhage (chemically induced) Humans Male Middle Aged Occult Blood Propionates (adverse effects)

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