Abstract |
The effect of aspirin (ASP), chlorpromazine (CPZ), diphenoxylate (DP), ethylene glycol tetraacetate ( EGTA), hydrocortisone (HC), loperamide (LPA), methylprednisolone (MP), phenotolamine mesylate (PTM), propranolol (PR), and trifluoperazine (TPZ) on the secretory activity induced by Escherichia coli heat-stable (ST) enterotoxin in infant mice was studied. LPA and DP, which are used therapeutically for diarrhea, did not inhibit the effect of ST enterotoxin; MP and HC, known inhibitors of cholera enterotoxin, and two adrenergic agents (PR and PTM) had no effect on ST-induced secretory activity. TPZ, EGTA, ASP, and CPZ caused a significant (P less than 0.05) decrease in the secretory activity induced by ST enterotoxin, CPZ, EGTA, and TPZ inhibited secretory activity induced by 8-bromoguanosine 3'5'-cyclic monophosphoric acid (8-BrcGMP), a cGMP analog.
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Authors | F C Knoop, D M Abbey |
Journal | Canadian journal of microbiology
(Can J Microbiol)
Vol. 27
Issue 8
Pg. 754-8
(Aug 1981)
ISSN: 0008-4166 [Print] Canada |
PMID | 6794896
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Enterotoxins
- Trifluoperazine
- Egtazic Acid
- Loperamide
- Diphenoxylate
- Propranolol
- Aspirin
- Chlorpromazine
- Hydrocortisone
- Methylprednisolone
- Phentolamine
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Topics |
- Animals
- Aspirin
(pharmacology)
- Chlorpromazine
(pharmacology)
- Diphenoxylate
(pharmacology)
- Egtazic Acid
(pharmacology)
- Enterotoxins
(pharmacology)
- Escherichia coli
(analysis)
- Hydrocortisone
(pharmacology)
- Intestinal Mucosa
(metabolism)
- Loperamide
(pharmacology)
- Methylprednisolone
(pharmacology)
- Mice
- Phentolamine
(pharmacology)
- Propranolol
(pharmacology)
- Trifluoperazine
(pharmacology)
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