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Effect of chemical and pharmacological agents on the secretory activity induced by Escherichia coli heat-stable enterotoxin.

Abstract
The effect of aspirin (ASP), chlorpromazine (CPZ), diphenoxylate (DP), ethylene glycol tetraacetate (EGTA), hydrocortisone (HC), loperamide (LPA), methylprednisolone (MP), phenotolamine mesylate (PTM), propranolol (PR), and trifluoperazine (TPZ) on the secretory activity induced by Escherichia coli heat-stable (ST) enterotoxin in infant mice was studied. LPA and DP, which are used therapeutically for diarrhea, did not inhibit the effect of ST enterotoxin; MP and HC, known inhibitors of cholera enterotoxin, and two adrenergic agents (PR and PTM) had no effect on ST-induced secretory activity. TPZ, EGTA, ASP, and CPZ caused a significant (P less than 0.05) decrease in the secretory activity induced by ST enterotoxin, CPZ, EGTA, and TPZ inhibited secretory activity induced by 8-bromoguanosine 3'5'-cyclic monophosphoric acid (8-BrcGMP), a cGMP analog.
AuthorsF C Knoop, D M Abbey
JournalCanadian journal of microbiology (Can J Microbiol) Vol. 27 Issue 8 Pg. 754-8 (Aug 1981) ISSN: 0008-4166 [Print] Canada
PMID6794896 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Enterotoxins
  • Trifluoperazine
  • Egtazic Acid
  • Loperamide
  • Diphenoxylate
  • Propranolol
  • Aspirin
  • Chlorpromazine
  • Hydrocortisone
  • Methylprednisolone
  • Phentolamine
Topics
  • Animals
  • Aspirin (pharmacology)
  • Chlorpromazine (pharmacology)
  • Diphenoxylate (pharmacology)
  • Egtazic Acid (pharmacology)
  • Enterotoxins (pharmacology)
  • Escherichia coli (analysis)
  • Hydrocortisone (pharmacology)
  • Intestinal Mucosa (metabolism)
  • Loperamide (pharmacology)
  • Methylprednisolone (pharmacology)
  • Mice
  • Phentolamine (pharmacology)
  • Propranolol (pharmacology)
  • Trifluoperazine (pharmacology)

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