Glycoprotein metabolism in the guinea-pig gastric mucosa in chronic metribuzin poisoning.

Abstract

Forty male guinea pigs weighting 400--600 g, 8 months old, were given metribuzin directly into the gastric lumen over a period of 30 days (20 animals) or 90 days (20 animals), 6 times a week. The intoxicated animals showed in the gastric mucosa a significant decrease in glucosamine isomerase activity and a significant increased in beta-glucosidase and beta-galactosidase activity. The results suggest that the biosynthesis of the sugar moiety of glycoproteins is depressed, the degradation of glycoproteins is stimulated by metribuzin.

• Authors: K Zwierz, J Tomaszewski, A Rózański, S Kreczko
• Journal: Acta biologica Academiae Scientiarum Hungaricae (Acta Biol Acad Sci Hung) Vol. 32 Issue 1 Pg. 69-73 ( 1981) ISSN: 0001-5288 [Print] Hungary
• PMID: 6792843 (Publication Type: Journal Article)

Chemical References

• Glycoproteins
• Herbicides
• Triazines
• Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
• Galactosidases
• Glucosidases
• beta-Glucosidase
• beta-Galactosidase
• Carbohydrate Epimerases
• metribuzin

Topics

• Animals
• Carbohydrate Epimerases (metabolism)
• Galactosidases (metabolism)
• Gastric Mucosa (drug effects, enzymology)
• Glucosidases (metabolism)
• Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) (metabolism)
• Glycoproteins (metabolism)
• Guinea Pigs
• Herbicides (toxicity)
• Kinetics
• Male
• Triazines (administration & dosage, toxicity)
• beta-Galactosidase (metabolism)
• beta-Glucosidase (metabolism)