[Experimental study of new cerebral protective substances--functional recovery of severe, incomplete ischemic brain pretreated with mannitol and fluorocarbon emulsion-- (author's transl)].

Using the "canine model of complete ischemic brain regulated with a perfusion method" in which it is possible to control the degree of blood flow to a cerebral hemisphere via a perfusion pump, the effects of mannitol (which acts as a free radical scavenger) and FC (which has 0.1 micrometer of average particle size and a high oxygen-carrying capacity) on cerebral ischemia were investigated. After pretreatment with the drugs, blood flow was reduced via the pump to 1/10 of the normal flow volume and 1 hr later, return to a normal flow was allowed. Subsequent changes in electrical activity were observed and the effects of the drugs evaluated. In the control group, no recovery of electrical activity was seen, but in the animals treated with either mannitol or FC, incomplete, yet distinct recovery was apparent. In the animals administered with mannitol together with FC, however, marked recovery was evident. These experimental results indicated that a combined administration of FC and mannitol is effective in protecting the brain from cerebral ischemia.
AuthorsK Mizoi, T Yoshimoto, J Suzuki
JournalNo shinkei geka. Neurological surgery (No Shinkei Geka) Vol. 9 Issue 8 Pg. 905-9 (Jul 1981) ISSN: 0301-2603 [Print] JAPAN
PMID6792553 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Fluorocarbons
  • Mannitol
  • Animals
  • Brain Ischemia (drug therapy, physiopathology)
  • Cerebrovascular Circulation
  • Dogs
  • Drug Synergism
  • Drug Therapy, Combination
  • Electroencephalography
  • Fluorocarbons (administration & dosage)
  • Mannitol (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: