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Chronic myeloid leukemia in Waldenström's macroglobulinemia.

Abstract
Eighteen months after the occurrence of Waldenström's macroglobulinemia, Philadelphia (Ph1) chromosome-positive chronic myeloid leukemia developed in a 69-year-old woman. The coexistence of the two disorders was characterized by an initial reduction of paraproteinemia at the time that leukemia occurred, a long-lasting remission of the two disorders, and a final parallel increase of paraproteins and WBCs. Since leukemia occurred 15 months after the interruption of melphalan therapy, the potential mutagenic role of chemotherapy was considered irrelevant. Therefore, Waldenström's macroglobulinemia might favor the occurrence of chronic myeloid leukemia.
AuthorsC Vitali, S Bombardieri, G Spremolla
JournalArchives of internal medicine (Arch Intern Med) Vol. 141 Issue 10 Pg. 1349-51 (Sep 1981) ISSN: 0003-9926 [Print] United States
PMID6791603 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Melphalan
Topics
  • Aged
  • Bone Marrow (pathology)
  • Chromosomes, Human, 21-22 and Y
  • Female
  • Humans
  • Leukemia, Myeloid (complications)
  • Melphalan (therapeutic use)
  • Time Factors
  • Waldenstrom Macroglobulinemia (complications, drug therapy)

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