Effects of 4-hydroxy, 4-phenyl, caproamide on pentylenetetrazol-induced amnesia.

Abstract

Early reports suggest a relationship between pentylenetetrazol-induced convulsions (PTZ) and amnesia. 4,-Hydroxy,4-phenyl caproamide (YPCA) is potently anti-convulsant against PTZ-induced convulsions. The purpose of these experiments is to show the possible role of PTZ in these amnestic effects. Experiment 1 proves YPCA antagonism of PTZ-induced convulsions in mice. Experiment 2 shows how YPCA, injected before PTZ and after animal training, protects against convulsions, leaving memory storage unaffected. However, when YPCA is injected before training (10 and 5 min) and PTZ 15 min afterwards (5 and 10 min after training), a retention impairment was observed. The results are discussed in terms that emphasize the need of convulsions in retrograde amnesia. Experiment 3 shows that foot shock is necessary for passive avoidance acquisition. Experiment 4 shows that subconvulsive doses of PTZ (5,10,20, and 40 mg/kg-1) have no effect on memory.

• Authors: A Oscós-Alvarado, D Martínez de Muñoz
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 74 Issue 1 Pg. 93-6 ( 1981) ISSN: 0033-3158 [Print] Germany
• PMID: 6791213 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amides
• Anticonvulsants
• Phenylbutyrates
• gamma-hydroxy-gamma-ethyl-gamma-phenylbutyramide
• Pentylenetetrazole

Topics

• Amides (pharmacology)
• Amnesia (chemically induced)
• Animals
• Anticonvulsants (pharmacology)
• Avoidance Learning (drug effects)
• Humans
• Male
• Mice
• Pentylenetetrazole (antagonists & inhibitors)
• Phenylbutyrates (pharmacology)