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Use of alpha-methylphenylalanine for studies of brain development in experimental phenylketonuria.

Abstract
Experimental phenylketonuria was induced in newborn rats by administration of L-phenylalanine and alpha-methylphenylalanine. There was no primary disturbance of myelination, but reduced cell proliferation, early cell death and compensatory hyperplasia were evident in the cerebellum.
AuthorsG Huether, V Neuhoff
JournalJournal of inherited metabolic disease (J Inherit Metab Dis) Vol. 4 Issue 2 Pg. 67-8 ( 1981) ISSN: 0141-8955 [Print] United States
PMID6790851 (Publication Type: Journal Article)
Chemical References
  • alpha-methylphenylalanine
  • Phenylalanine
  • Phenylalanine Hydroxylase
Topics
  • Animals
  • Brain (growth & development)
  • Cell Division (drug effects)
  • Cell Survival (drug effects)
  • Cerebellum (cytology)
  • Disease Models, Animal
  • Humans
  • Phenylalanine (analogs & derivatives, pharmacology)
  • Phenylalanine Hydroxylase (antagonists & inhibitors)
  • Phenylketonurias (chemically induced, pathology)
  • Rats

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