Abstract |
A variety of naphthoquinones have veen prepared and evaluated in vitro against the causative agent of the cattle disease East Coast Fever-Theileria parva infection. It is concluded from structure-activity studies that a 2-hydroxyl moiety es essential for high activity. The most active compounds tested were 2-hydroxy-3-alkyl-1,4-naphthoquinones in which the alkyl moiety was cyclohexyl, cyclohexylcyclohexyl, tridecyl, or tetradecyl.
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Authors | P Boehm, K Cooper, A T Hudson, J P Elphick, N McHardy |
Journal | Journal of medicinal chemistry
(J Med Chem)
Vol. 24
Issue 3
Pg. 295-9
(Mar 1981)
ISSN: 0022-2623 [Print] United States |
PMID | 6790703
(Publication Type: Journal Article)
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Chemical References |
- Antiprotozoal Agents
- Naphthoquinones
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Topics |
- Animals
- Antiprotozoal Agents
(chemical synthesis, pharmacology)
- Apicomplexa
(drug effects)
- Cattle
- Naphthoquinones
(chemical synthesis, pharmacology)
- Structure-Activity Relationship
- Theileriasis
(parasitology)
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