Bioavailability of some lysine derivatives in mice.

Abstract

Growth assays using mice on synthetic amino acid diets showed that substituting epsilon-N-methyl-L-lysine, epsilon-N-dimethyl-L-lysine and epsilon-N-trimethyl-L-lysine for lysine resulted in relative replacement values about 1/12, 1/20 and 1/25, respectively, of that obtained with the standard lysine diet. Similar studies showed that the alpha-N-acetyl-L-lysine is not utilized by mice and that the relative the replacement value of epsilon-N-acetyl-L-lysine was about 3% of that of lysine. Analogous substitution of D-lysine and the lysine sulfur-containing analog, S-(2-aminoethyl)-L-cysteine, for lysine resulted in weight losses during the feeding period. The results are discussed with reference to factors that are expected to influence the biological utilization f lysine analogs and derivatives.

• Authors: M Friedman, M R Gumbmann
• Journal: The Journal of nutrition (J Nutr) Vol. 111 Issue 8 Pg. 1362-9 (Aug 1981) ISSN: 0022-3166 [Print] United States
• PMID: 6790681 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dietary Proteins
• epsilon-N-methyllysine
• epsilon N-dimethyllysine
• S-2-aminoethyl cysteine
• trimethyllysine
• Lysine
• Cysteine

Topics

• Animals
• Biological Assay
• Biological Availability
• Body Weight
• Cysteine (analogs & derivatives, metabolism)
• Dietary Proteins (metabolism)
• Lysine (analogs & derivatives, metabolism)
• Mice
• Structure-Activity Relationship