Abstract |
A single intravenous (i.v.) injection of the water-soluble mammary carcinogen N-nitroso-N- methylurea (NMU; 35 mg/kg of body weight) elicited cancer of the breast in young female rats of two strains in the following incidence: Long-Evans strain, 4%; Sprague-Dawley strain, 70%. In sisters of these rats, a set of 5 i.v. injections of NMU (35 mg/kg at biweekly intervals) evoked mammary carcinoma as follows: Long-Evans strain, 76%; Sprague-Dawley strain, 100%. In its effectiveness in evoking mammary cancer in Sprague-Dawley rats, the lipid-soluble mammary carcinogen 7,8,12-trimethylbenz[a] anthracene exceeded NMU in rapidity of development of cancer and in tumor yield.
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Authors | C B Huggins, N Ueda, M Wiessler |
Journal | Proceedings of the National Academy of Sciences of the United States of America
(Proc Natl Acad Sci U S A)
Vol. 78
Issue 2
Pg. 1185-8
(Feb 1981)
ISSN: 0027-8424 [Print] United States |
PMID | 6785750
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Nitrosourea Compounds
- 7,8,12-trimethylbenz(a)anthracene
- 9,10-Dimethyl-1,2-benzanthracene
- Methylnitrosourea
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Topics |
- 9,10-Dimethyl-1,2-benzanthracene
(analogs & derivatives)
- Animals
- Drug Resistance
- Female
- Mammary Neoplasms, Experimental
(chemically induced, pathology)
- Methylnitrosourea
- Nitrosourea Compounds
- Rats
- Species Specificity
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