Oral photochemotherapy in the treatment of lichen planus (LP). Clinical results, histological and ultrastructural observations.

Abstract

Seven patients with diffuse lichen planus were treated with oral photochemotherapy. Remission was effected in 6 cases. The only failure may be attributable to a low UVA dose. Histological examination after treatment showed disappearance of the superficial dermal lymphocytic infiltrate. Ultrastructural study revealed nuclear alterations of keratinocytes and nuclear and cytoplasmic changes in superficial dermal cells. Various theories concerning the mode of action of photochemotherapy in lichen planus are discussed in the light of these observations.

• Authors: J P Ortonne, J Thivolet, C Sannwald
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 99 Issue 1 Pg. 77-88 (Jul 1978) ISSN: 0007-0963 [Print] England
• PMID: 678468 (Publication Type: Journal Article)

Chemical References

• Methoxsalen

Topics

• Adult
• Aged
• Child
• Female
• Humans
• Lichen Planus (drug therapy, pathology)
• Male
• Methoxsalen (therapeutic use)
• Middle Aged
• Photochemotherapy
• Radiotherapy Dosage
• Skin (ultrastructure)