The inhibition of PGI2 synthetase within the arterial wall by 15-hydroperoxyarachidonic acid enhances local white platelet thrombosis.

Abstract	Prostaglandins play an important role in platelet-vessel wall interaction. The inhibition of PGI2 synthetase by 15-hydroxyarachidonic acid (15-HPAA) results in an enhancement of local thrombus formation.
Authors	R H Bourgain
Journal	Haemostasis (Haemostasis) Vol. 9 Issue 6 Pg. 345-51 ( 1980) ISSN: 0301-0147 [Print] Switzerland
PMID	6778799 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Arachidonic Acids Cyclooxygenase Inhibitors Leukotrienes Lipid Peroxides Peroxides Prostaglandins 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid Epoprostenol
Topics	Animals Arachidonic Acids (pharmacology) Arteries (enzymology) Blood Platelets (drug effects) Cyclooxygenase Inhibitors Epoprostenol (biosynthesis) In Vitro Techniques Leukotrienes Lipid Peroxides Male Peroxides (pharmacology) Platelet Aggregation (drug effects) Prostaglandins (biosynthesis) Rats Thrombosis (chemically induced)

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