Extremely high titers of serum antibodies against the streptococcal exoenzyme deoxyribonuclease B.

Abstract

In sera from 4 of 25,000 individuals tested for antibodies against streptococci, extremely high antideoxyribonuclease B titers ( > 10(6) U/ml) were found. Two of the cases were diagnosed as monoclonal gammopathies. The M-components were shown to possess the anti-deoxyribonuclease B activity. The other two cases were diagnosed as relapsing erysipelas. The high serum titers of deoxyribonuclease B antibodies were accompanied by a very inflammatory reactivity in the patients' sera and by an oligopolyclonal pattern of immunoglobulin G. In routine diagnoses of streptococcal infections with the anti-deoxyribonuclease B test, patients with extremely high serum titers should be examined for the possible occurrence of gammopathies.

• Authors: B Hederstedt, S E Holm, R Norberg
• Journal: Journal of clinical microbiology (J Clin Microbiol) Vol. 11 Issue 6 Pg. 720-3 (Jun 1980) ISSN: 0095-1137 [Print] United States
• PMID: 6776140 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Antibodies, Bacterial
• Immunoglobulin A
• Immunoglobulin G
• Antistreptolysin
• Deoxyribonucleases

Topics

• Adult
• Aged
• Antibodies, Bacterial (analysis)
• Antistreptolysin (analysis)
• Deoxyribonucleases (immunology)
• Erysipelas (immunology)
• Female
• Humans
• Hypergammaglobulinemia (immunology)
• Immunodiffusion
• Immunoglobulin A
• Immunoglobulin G
• Male
• Middle Aged
• Streptococcus (enzymology, immunology)