Phenobarbital vs. phenytoin for grand mal epilepsy.

The chief side effect of phenobarbital is drowsiness, which is usually associated with overdosage. Phenytoin, on the other hand, causes gingival hyperplasia in many patients, irreversible hypertrichosis in some patients and lethal reactions, such as Stevens-Johnson syndrome, in a few patients. Antiepileptic therapy should always be started with one drug. Phenytoin is specifically contraindicated as the drug of first choice for infants, females (especially adolescents) and children receiving orthodontic treatment.
AuthorsS Livingston, L L Pauli, I Pruce, I I Kramer
JournalAmerican family physician (Am Fam Physician) Vol. 22 Issue 2 Pg. 123-7 (Aug 1980) ISSN: 0002-838X [Print] UNITED STATES
PMID6773400 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Phenytoin
  • Phenobarbital
  • Adolescent
  • Age Factors
  • Anticonvulsants (administration & dosage)
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Epilepsy, Tonic-Clonic (drug therapy)
  • Female
  • Gingival Hyperplasia (chemically induced)
  • Humans
  • Hyperkinesis (chemically induced)
  • Hypertrichosis (chemically induced)
  • Male
  • Methods
  • Orthodontics, Corrective
  • Phenobarbital (adverse effects)
  • Phenytoin (adverse effects)
  • Stevens-Johnson Syndrome (chemically induced)

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