Repair of DNA damage after exposure to 4-nitroquinoline-1-oxide in heterokaryons derived from xeroderma pigmentosum cells.

Abstract

Xeroderma pigmentosum (XP) cells are deficient in the repair of damage induced by ultraviolet irradiation. Excision-repair-deficient XP cell strains have been classified into 7 distinct complementation groups, according to results of studies on cell fusion and UV irradiation. XP cells are not only abnormally sensitive to UV, but also to a variety of chemical carcinogens, including 4-nitro-quinoline-1-oxide (4NQO). Complementation analysis with XP strains from 4 different complementation groups with respect to the repair of 4NQO-induced DNA damage revealed that the classification of the strains into complementation groups with respect to 4NQO-induced repair coincides with the classification based on the repair of UV damage.

• Authors: B Zelle, D Bootsma
• Journal: Mutation research (Mutat Res) Vol. 70 Issue 3 Pg. 373-81 (May 1980) ISSN: 0027-5107 [Print] Netherlands
• PMID: 6770261 (Publication Type: Journal Article)

Chemical References

• Mutagens
• Nitroquinolines
• 4-Nitroquinoline-1-oxide
• DNA

Topics

• 4-Nitroquinoline-1-oxide (pharmacology)
• Cell Fusion
• Cell Line
• Cell Nucleus
• DNA (metabolism)
• DNA Repair
• Genetic Complementation Test
• Heterozygote
• Humans
• Mutagens
• Nitroquinolines (pharmacology)
• Skin
• Xeroderma Pigmentosum (genetics, pathology)