Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy.

Abstract

THIP, 4,5,6,7-tetra hydroisoxazolo[5,4-C]pyridine-3-ol, has been evaluated as an anticonvulsant in DBA/2 mice showing audiogenic seizures, and in baboons, Papio papio, with photosensitive epilepsy. No protection against seizures was seen after THIP, 1-4 mg/kg, intraperitoneally in mice. THIP, 8 mg/kg, reduced clonic and subsequent seizure responses at 1 h. It also reduced rectal temperature and impaired posture and spontaneous activity. In baboons THIP, 0.25-8 mg/kg, iv, failed to protect against photically induced myoclonic responses. Toxic signs after THIP, 8 mg/kg, included focal or generalised myoclonus. THIP is thus not effective against reflex epilepsy.

• Authors: B Meldrum, R Horton
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 61 Issue 3 Pg. 231-7 (Feb 08 1980) ISSN: 0014-2999 [Print] Netherlands
• PMID: 6767614 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Isoxazoles
• Oxazoles
• gamma-Aminobutyric Acid
• gaboxadol

Topics

• Animals
• Anticonvulsants
• Electroencephalography
• Haplorhini
• Isoxazoles (pharmacology)
• Mice
• Mice, Inbred DBA
• Myoclonus (physiopathology)
• Oxazoles (pharmacology)
• Papio
• Photic Stimulation
• Seizures (physiopathology)
• Time Factors
• gamma-Aminobutyric Acid (physiology)