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[Grafts of human skin containing nevi or superficial nevocarcinoma onto athymic nu/nu mice: macroscopic and microscopic studies].

Abstract
17 thin grafts of corpse skin containing neavi, were grafted onto the back of athymic mice. All the grafts took. The naevi were than deeply incised on 3 occasions. No evidence of abnormal healing, of pigment release, or of malignant transformation, appeared. 10 epidermal grafts of superficial malignant melanoma, taken from 4 different patients, took successfully. In 7 of these, superficial ulcerations appeared but were definitively re-epithelialised from the adjacent Mouse skin. 5 and 7 months later, the melanoma are stable, without local extensions, infiltration or apparent metastase. Despite the absence of an inflammatory reaction, these melanoma are paradoxically quiescent in nude Mice.
AuthorsA Duprez
JournalComptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles (C R Seances Acad Sci D) Vol. 290 Issue 6 Pg. 461-4 (Feb 11 1980) ISSN: 0567-655X [Print] France
Vernacular TitleGreffes chez la Souis athymique nu/nu de peaux humaines porteuses de naevi ou de naevocarcinomes superficiels : étude macroscopique et microscopique.
PMID6767555 (Publication Type: English Abstract, Journal Article)
Topics
  • Animals
  • Cell Transformation, Neoplastic (pathology)
  • Graft Survival
  • Humans
  • Male
  • Melanoma (pathology)
  • Mice
  • Mice, Nude
  • Neoplasm Metastasis
  • Neoplasm Transplantation
  • Nevus (pathology)
  • Skin (pathology)
  • Skin Neoplasms (pathology)
  • Skin Pigmentation
  • Skin Transplantation
  • Transplantation, Heterologous (methods)

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