Danazol and stanozolol in long-term prophylactic treatment of hereditary angioedema.

Abstract

Treatment with 17 alpha-methyltestosterone and with some synthetic androgens prevents attacks of hereditary angioedema (HAE). However, the potential hepatotoxicity of 17 alpha-alkylated androgens raises the problem of long-term prophylactic use of these agents. Therefore we compared the efficacy in preventing HAE attacks of 17 alpha-alkylated steroids (danazol and stanozolol) with non-17 alpha-alkylated derivatives (quinbolone, nandrolone decanoate and mesterolone). As the latter group proved ineffective, it seems that a drug's efficacy in preventing HAE attacks is connected to its 17 alpha-alkylation. Moreover, our long-term observations with the minimum effective dose of danazol seem to indicate the absence of important collateral effects.

• Authors: A Agostoni, M Cicardi, G C Martignoni, L Bergamaschini, B Marasini
• Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 65 Issue 1 Pg. 75-9 (Jan 1980) ISSN: 0091-6749 [Print] United States
• PMID: 6765962 (Publication Type: Journal Article)

Chemical References

• Androstadienes
• Complement C1 Inactivator Proteins
• Complement C4
• Pregnadienes
• Mesterolone
• Stanozolol
• Nandrolone
• Danazol
• quinbolone

Topics

• Adult
• Androstadienes (administration & dosage)
• Angioedema (drug therapy, genetics)
• Complement C1 Inactivator Proteins
• Complement C4
• Danazol (administration & dosage, adverse effects, therapeutic use)
• Female
• Humans
• Long-Term Care
• Male
• Mesterolone (administration & dosage)
• Middle Aged
• Nandrolone (administration & dosage)
• Pregnadienes (administration & dosage)
• Stanozolol (administration & dosage, therapeutic use)