| Abstract | Treatment with 17 alpha-methyltestosterone and with some synthetic androgens prevents attacks of hereditary angioedema (HAE). However, the potential hepatotoxicity of 17 alpha-alkylated androgens raises the problem of long-term prophylactic use of these agents. Therefore we compared the efficacy in preventing HAE attacks of 17 alpha-alkylated steroids (danazol and stanozolol) with non-17 alpha-alkylated derivatives (quinbolone, nandrolone decanoate and mesterolone). As the latter group proved ineffective, it seems that a drug's efficacy in preventing HAE attacks is connected to its 17 alpha-alkylation. Moreover, our long-term observations with the minimum effective dose of danazol seem to indicate the absence of important collateral effects. |
| Authors | A Agostoni, M Cicardi, G C Martignoni, L Bergamaschini, B Marasini |
| Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 65
Issue 1
Pg. 75-9
(Jan 1980)
ISSN: 0091-6749 UNITED STATES |
| PMID | 6765962
(Publication Type: Journal Article)
|
| Chemical References |
- Androstadienes
- Complement C1 Inactivator Proteins
- Complement C4
- Pregnadienes
- Stanozolol
- Mesterolone
- Danazol
- Nandrolone
|
| Topics |
- Adult
- Androstadienes
(administration & dosage)
- Angioedema
(drug therapy, genetics)
- Complement C1 Inactivator Proteins
- Complement C4
- Danazol
(administration & dosage, adverse effects, therapeutic use)
- Female
- Humans
- Long-Term Care
- Male
- Mesterolone
(administration & dosage)
- Middle Aged
- Nandrolone
(administration & dosage)
- Pregnadienes
(administration & dosage)
- Stanozolol
(administration & dosage, therapeutic use)
|
