[Effect of a synthetic analog of enkephalin on the choreic syndrome].

Abstract

A cross-over, double-blind intravenous administration of a single dose of FK 33-824, a rigid analog of enkephalin, was performed in 12 choreic patients (0,5 mg in 6 patients, 2 mg in 6 patients). The number of abnormal involuntary movements per minute and their amplitude was not altered after FK 33-824 when compared to placebo administration. This result however does not exclude the possibility of a functional interaction between Met-enkephalinergic and dopaminergic systems in the human brain.

• Authors: A Destée, H Petit, P Warot, F Lhermitte, Y Agid
• Journal: Revue neurologique (Rev Neurol (Paris)) Vol. 138 Issue 11 Pg. 845-9 ( 1982) ISSN: 0035-3787 [Print] France
• Vernacular Title: Effet d'un analogue synthétique de l'enképhaline dans le syndrome choréïque.
• PMID: 6762632 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Enkephalin, Methionine
• D-Ala(2),MePhe(4),Met(0)-ol-enkephalin

Topics

• Adult
• Aged
• Chorea (drug therapy)
• Clinical Trials as Topic
• D-Ala(2),MePhe(4),Met(0)-ol-enkephalin
• Double-Blind Method
• Enkephalin, Methionine (analogs & derivatives, therapeutic use)
• Female
• Humans
• Male
• Middle Aged