[Treatment of ulcers with pirenzepin. Results from clinic and practice].

Abstract

In two studies the beneficial effect of Pirenzepine in the treatment of peptic duodenal and gastric ulcers was investigated in 1686 outpatients. Study 1 includes patients treated and controlled mainly in hospitals, in study 2 treatment and control was performed mainly by practitioners. After four weeks of treatment healing of duodenal ulcers was observed in 68% of the patients in study 1 and 66% in study 2. Healing of peptic gastric ulcers was observed in 62% of the patients in study 1 and 53% of the patients in study 2. Mild anticholinergic side effects were observed in approximately 10% of the patients. Healing rates under Pirenzepine are similar those reported for Cimetidin or Carbenoxolon. It is concluded that Pirenzepine has a beneficial effect in the treatment of peptic duodenal and gastric ulcer disease.

• Authors: F Krempler, F Sandhofer, A Kalk
• Journal: Wiener medizinische Wochenschrift (1946) (Wien Med Wochenschr) Vol. 132 Issue 18 Pg. 427-32 (Sep 30 1982) ISSN: 0043-5341 [Print] Austria
• Vernacular Title: Ulkusbehandlung mit Pirenzepin. Ergebnisse aus Klinik und Praxis.
• PMID: 6760563 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Anti-Ulcer Agents
• Benzodiazepinones
• Pirenzepine
• Cimetidine
• Carbenoxolone

Topics

• Adult
• Anti-Ulcer Agents (therapeutic use)
• Benzodiazepinones (therapeutic use)
• Carbenoxolone (therapeutic use)
• Chemical Phenomena
• Chemistry
• Cimetidine (therapeutic use)
• Clinical Trials as Topic
• Duodenal Ulcer (drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Peptic Ulcer (drug therapy)
• Pirenzepine
• Stomach Ulcer (drug therapy)