HLA typing in non-Hodgkin's lymphomas. Comparative study in Caucasoids, Mexican-Americans and Negroids.

Abstract

Over 200 cases of non-Hodgkin's lymphoma were typed for HLA-A, B, C and DR antigens, and typing was correlated with the morphologic diagnosis according to the Lukes-Collins classification system of non-Hodgkin's lymphomas. Three major racial groups were represented: Caucasoids, Mexican-Americans and Negroids. Significant associations were observed between HLA-AW33 and Caucasoid B-cell lymphomas, and for HLA AW24, HLA-B37 and HLA-B40 and B cell lymphomas in Negroids. No significant correlations were found within the Mexican-American patient population. The number of T cell lymphomas was insufficient to draw any conclusions. The DR antigens were not significantly associated with any of the diagnostic subgroups.

• Authors: J G van den Tweel, D J Dugas, J Loon, R J Lukes
• Journal: Tissue antigens (Tissue Antigens) Vol. 20 Issue 5 Pg. 364-71 (Nov 1982) ISSN: 0001-2815 [Print] England
• PMID: 6760459 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• HLA Antigens
• HLA-B Antigens

Topics

• B-Lymphocytes (immunology)
• Black People
• Cytotoxicity Tests, Immunologic
• HLA Antigens (analysis, genetics, immunology)
• HLA-B Antigens
• Hispanic or Latino
• Humans
• Lymphoma (classification, immunology)
• Lymphoma, Follicular (immunology)
• Mexico (ethnology)
• White People