Comparative studies on immunological properties of antitumor polysaccharide TC-13.

Abstract

The biological and immunological characteristics of TC-13, an antitumor protein-bound polysaccharide, were studied. TC-13 had no direct cytocidal effect on Ehrlich carcinoma, but it induced antitumor resistance in mice whose tumors were regressed by TC-13. TC-13 changed the electrophoretic pattern of serum proteins of mice after its ip administration, causing a slow increase of the LB component and a rapid increase of the X component. TC-13 augmented the delayed-type hypersensitivity reaction to tumor homogenate, anti-SRBC antibody formation and the cytocidal activity of macrophages in an antibody-dependent system, but it had little or no effect on blast formation of spleen lymphocytes or carbon clearance. These results and comparative studies with other immunomodulators suggest that TC-13 is a unique polysaccharide having properties intermediate between those of lentinan, a simple-structured homologous polysaccharide from basidiomycetes, and lipopolysaccharide, a cell-surface component from bacteria.

• Authors: M Kohno, S Abe, H Nakajima, M Yamazaki, D Mizuno
• Journal: Gan (Gan) Vol. 73 Issue 4 Pg. 618-26 (Aug 1982) ISSN: 0016-450X [Print] Japan
• PMID: 6759288 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Antineoplastic Agents
• Glycopeptides
• Glycoproteins
• Polysaccharides, Bacterial
• TC 13

Topics

• Animals
• Anti-Bacterial Agents
• Antibody-Dependent Cell Cytotoxicity (drug effects)
• Antineoplastic Agents (immunology)
• Blood Protein Electrophoresis
• Carcinoma, Ehrlich Tumor (immunology)
• Cells, Cultured
• Glycopeptides
• Glycoproteins (immunology, pharmacology)
• Hemolytic Plaque Technique
• Hypersensitivity, Delayed (immunology)
• Lymphocyte Activation (drug effects)
• Macrophages (immunology)
• Male
• Mice
• Polysaccharides, Bacterial (immunology, pharmacology)