Double-blind comparative clinical trial of carprofen versus diclofenac-Na in patients with coxarthrosis.

Abstract

A randomized double-blind trial was performed in 50 patients with moderate to severe coxarthrosis, 25 receiving 300 mg carprofen and 25 150 mg diclofenac-Na daily in 3 doses. The patients were treated for 21 days. With regard to clinical effect (anti-inflammatory and analgesic), both carprofen and diclofenac-Na exhibited good efficacy; statistical evaluation failed to reveal a significant difference between the therapy groups for the parameters considered (Fisher's exact test, Mann-Whitney U-test). Few adverse reactions were registered; they were severe enough to justify interruption of treatment in 1 patient receiving carprofen and 3 receiving diclofenac-Na.

• Authors: O Knüsel
• Journal: European journal of rheumatology and inflammation (Eur J Rheumatol Inflamm) Vol. 5 Issue 4 Pg. 536-42 ( 1982) ISSN: 0140-1610 [Print] England
• PMID: 6759139 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Carbazoles
• Phenylacetates
• Diclofenac
• carprofen

Topics

• Adult
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Carbazoles (therapeutic use)
• Clinical Trials as Topic
• Diclofenac (therapeutic use)
• Double-Blind Method
• Female
• Hip Joint
• Humans
• Male
• Middle Aged
• Osteoarthritis (drug therapy)
• Phenylacetates (therapeutic use)
• Random Allocation