Reduction of the incidence of decompression sickness in rats by smooth-muscle activating factor (SMAF).

Abstract

Normal rats were injected with a smooth-muscle activating factor (SMAF) to examine the dose-response relationshio of SMAF to the incidence of decompression sickness. After injections of saline or 1.0, 5.0, or 10.0 mg/kg SMAF, the animals were compressed to 6 ATA breathing air for 1 h and were then rapidly decompressed to 1 ATA. Results indicate that predive injections of SMAF or exposure to the SMAF substance protected rats against decompression sickness and that higher doses appear to offer more protection.

• Authors: J M Walsh, J Vorosmarti Jr
• Journal: Undersea biomedical research (Undersea Biomed Res) Vol. 5 Issue 2 Pg. 129-35 (Jun 1978) ISSN: 0093-5387 [Print] United States
• PMID: 675878 (Publication Type: Journal Article)

Chemical References

• Peptides

Topics

• Animals
• Decompression Sickness (prevention & control)
• Female
• Muscle, Smooth
• Peptides (pharmacology)
• Rats