Endogenous renin inhibitor in neuroblastoma cells.

Abstract

Cloned neuroblastoma cells (Neuro-2a) in culture were found to contain a renin inhibitory substance. The inhibitor in the extract of cloned neuroblastoma cells was separated from renin activity by anti-renin IgG-Sepharose and selectively concentrated by adsorption to renin-agarose gel. The present study demonstrated the coexistence of renin and its inhibitor in the same cell and suggested a possible regulatory mechanism of intracellular renin activity by an endogenous renin inhibitor in neuronal cells.

• Authors: T Inagaki, T Okamura, T Inagami
• Journal: Brain research (Brain Res) Vol. 250 Issue 2 Pg. 373-7 (Nov 04 1982) ISSN: 0006-8993 [Print] Netherlands
• PMID: 6756543 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Oligopeptides
• renin inhibitory peptide
• Renin

Topics

• Animals
• Cell Line
• Mice
• Neoplasms, Experimental (metabolism)
• Neuroblastoma (metabolism)
• Neurons (metabolism)
• Oligopeptides (metabolism)
• Renin (antagonists & inhibitors)