Comparison of the effects of two prostaglandin F2 alpha analogues-estrumate and lutalyse on the volume, activity, and proteolytic power of the abomasal juice in sheep.

Abstract

The investigations were carried out on 7 wethers with cannulated fistulas of the "small" abomasum and rumen. In two series of experiments the optimal dose of one of the tested analogues of PGF 2 alpha (Estrumate 3-4 microgram/kg, Lutalyse 130-170 microgram/kg of body weight) was used. It was found the Estrumate in relation to Lutalyse caused a highly statistical significant rise (P less than 0.01) in the volume of secreted juice, free HCl, and total acidity in the same sheep. The specific activity (Anson mU/ml) increased more after Lutalyse (P less than 0.01) than after Estrumate injection. This analogue also caused significant (P less than 0.02) changes in the total activity (specific activity X juice volume of this sample). The obtained results expressed in per cent indicate that Estrumate exerts a greater effects on the parietal cells in the abomasal mucosa in sheep and Lutalyse stimulates more strongly the chief cells, as reflected in increased proteolytic power of the studied juice.

• Authors: J Dejneka, J Lukaszewska, K Romański
• Journal: Acta physiologica Polonica (Acta Physiol Pol) 1981 Nov-Dec Vol. 32 Issue 6 Pg. 659-66 ISSN: 0044-6033 [Print] Poland
• PMID: 6756033 (Publication Type: Journal Article)

Chemical References

• Prostaglandins F, Synthetic
• Cloprostenol
• Dinoprost
• dinoprost tromethamine
• Peptide Hydrolases

Topics

• Abomasum (drug effects, metabolism)
• Animals
• Cloprostenol (pharmacology)
• Dinoprost (analogs & derivatives)
• Kinetics
• Peptide Hydrolases (metabolism)
• Prostaglandins F, Synthetic (pharmacology)
• Sheep
• Structure-Activity Relationship