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Bactericidal activity of serum for Klebsiella rhinoscleromatis: studies on serum from a patient with rhinoscleroma and sera deficient in antibody or complement.

Abstract
The in-vitro bactericidal effect of serum for Klebsiella rhinoscleromatis was tested. Experiments with C2-deficient and hypogammaglobulinaemic human sera suggested that killing depended on activation of the classical complement pathway, although the alternative pathway probably amplified the effect. Serum from a patient with active rhinoscleroma, and another cured of the disease, showed normal killing.
AuthorsM E North, C A Newton, D J Wright, A D Webster
JournalJournal of medical microbiology (J Med Microbiol) Vol. 15 Issue 2 Pg. 267-72 (May 1982) ISSN: 0022-2615 [Print] England
PMID6754946 (Publication Type: Journal Article)
Chemical References
  • Complement C2
Topics
  • Agammaglobulinemia (immunology)
  • Blood Bactericidal Activity
  • Complement C2 (deficiency)
  • Granuloma (immunology)
  • Humans
  • Klebsiella Infections (immunology)
  • Klebsiella pneumoniae (immunology, metabolism)
  • Nasopharyngeal Diseases (immunology)

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