Clinical comparison of alclometasone dipropionate and desonide ointments (0.05%) in the management of psoriasis.

Abstract

This was a double-blind, randomized, parallel-groups comparison of alclometasone dipropionate and desonide ointments (0.05%) applied twice daily without occlusion for 3 weeks by patients with moderate to severe psoriasis. Data from thirty-three patients in each group showed that both treatments produced rapid amelioration of erythema, induration, and, especially, scaling; substantial improvement was evident after 1 week and continued thereafter. Differences between the groups were not statistically significant, but trends consistently favoured alclometasone. No adverse drug reaction occurred.

• Authors: P Frost, S N Horwitz
• Journal: The Journal of international medical research (J Int Med Res) Vol. 10 Issue 5 Pg. 375-8 ( 1982) ISSN: 0300-0605 [Print] England
• PMID: 6754511 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Ointments
• Pregnadienetriols
• Desonide
• alclometasone dipropionate
• Methylprednisolone

Topics

• Administration, Topical
• Adolescent
• Adult
• Aged
• Clinical Trials as Topic
• Desonide (administration & dosage, therapeutic use)
• Double-Blind Method
• Female
• Humans
• Male
• Methylprednisolone (administration & dosage, analogs & derivatives, therapeutic use)
• Middle Aged
• Ointments
• Pregnadienetriols (therapeutic use)
• Psoriasis (drug therapy)