Abstract |
The haemodynamic response and pharmacokinetics of single dose oral tolmesoxide were studied at various dose levels in 4 patients with severe hypertension. There was a reproducible fall in mean arterial pressure from baseline of 24.2% and a rise in heart rate of 37.6% following administration of tolmesoxide. The onset of antihypertensive action occurred within 1 h, with a peak effect at 3 h after dosing. The mean duration of action was up to 12.0 h. Tolmesoxide had a mean half-life of 3.0 h. It was rapidly absorbed with a mean peak plasma level occurring at 1.0 h. Plasma levels correlated well with the doses administered. Side-effects include mild nausea, facial flushing and postural symptoms.
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Authors | C P O'Boyle, M Laher, E T O'Brien, K O'Malley, J G Kelly |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 23
Issue 2
Pg. 93-7
( 1982)
ISSN: 0031-6970 [Print] Germany |
PMID | 6754385
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Sulfoxides
- tolmesoxide
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Topics |
- Aged
- Antihypertensive Agents
(adverse effects, blood, therapeutic use)
- Blood Pressure
(drug effects)
- Clinical Trials as Topic
- Double-Blind Method
- Humans
- Hypertension
(drug therapy)
- Middle Aged
- Sulfoxides
(adverse effects, blood, therapeutic use)
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