Trachoma therapy with topical tetracycline and oral erythromycin: a comparative trial.
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| Abstract |
Because topical antibiotic treatment has had a limited effect in previous controlled trials against trachoma, treatment with oral erythromycin was compared with topical tetracycline in 6-8-year-old children in southern Tunisia who had potentially blinding active trachoma. A total of 169 children were divided into two groups that were carefully matched for age, sex, locality, and intensity of disease. Oral erythromycin ethyl succinate in a paediatric dosage form was administered to one group and topical 1% tetracycline ointment to the other group, twice daily, six days a week for three weeks. The two treatments were equivalent in effectiveness and resulted in a substantial decrease in disease intensity and a marked reduction in chlamydial infection detected in conjunctival smears. To maintain blood levels of antibiotics known to be effective in the treatment of chlamydial infections with a dosage schedule possible in a trachoma control programme, one of the long-acting tetracyclines (doxycycline or minocycline) might be considered. Such systemic chemotherapy should be limited to selective treatment of individuals who can be adequately monitored.
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| Authors | C R Dawson, T Daghfous, I Hoshiwara, K Ramdhane, M Kamoun, C Yoneda, J Schachter |
| Journal | Bulletin of the World Health Organization (Bull World Health Organ) Vol. 60 Issue 3 Pg. 347-55 ( 1982) ISSN: 0042-9686 [Print] Switzerland |
| PMID | 6754118 (Publication Type: Case Reports, Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.) |
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