A clinical evaluation of the effects of topically applied levobunolol and timolol on increased intraocular pressure.

Abstract

Data from two short-term double-masked studies using 24 and 16 subjects suggest that topically applied levobunolol safely and effectively treats open-angle glaucoma and ocular hypertension. The onset of effect of a single drop of 0.5% levobunolol occurred within the first hour, producing a maximal hypotensive effect of more than 8 mm Hg after two hours. An intraocular pressure deceased of greater than or equal to 2 mm Hg was still observed after 24 hours for both concentrations of levobunolol tested (0.5% and 1%). Intraocular pressure decreases of more than 9 mm Hg persisted during a one-month trial in which patients were treated twice daily, confirming the results obtained in the 24-hour study. Systemic effects of both timolol (0.5%) and levobunolol (0.5% and 1%) included a consensual intraocular pressure-decreasing effect in the untreated eye and clinically significant reductions in heart rate. Diastolic blood pressure was decreased at two and four hours after administration of 0.5% levobunolol.

• Authors: E Duzman, M Ober, A Scharrer, I H Leopold
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 94 Issue 3 Pg. 318-27 (Sep 1982) ISSN: 0002-9394 [Print] United States
• PMID: 6751091 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Propanolamines
• Timolol
• Levobunolol

Topics

• Administration, Topical
• Aged
• Blood Pressure (drug effects)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Glaucoma (drug therapy)
• Glaucoma, Open-Angle (drug therapy)
• Humans
• Intraocular Pressure (drug effects)
• Levobunolol (administration & dosage)
• Male
• Propanolamines (administration & dosage)
• Time Factors
• Timolol (administration & dosage)