Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi.

Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide-linked enzymes (alpha-hydroxyacid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.
AuthorsE E Montamat, C Burgos, N M Gerez de Burgos, L E Rovai, A Blanco, E L Segura
JournalScience (New York, N.Y.) (Science) Vol. 218 Issue 4569 Pg. 288-9 (Oct 15 1982) ISSN: 0036-8075 [Print] UNITED STATES
PMID6750791 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Oxidoreductases
  • Alcohol Oxidoreductases
  • Lactate Dehydrogenases
  • L-Lactate Dehydrogenase
  • D-lactate dehydrogenase
  • Malate Dehydrogenase
  • D-2-hydroxyacid dehydrogenase
  • Gossypol
  • Alcohol Oxidoreductases (metabolism)
  • Gossypol (pharmacology)
  • L-Lactate Dehydrogenase
  • Lactate Dehydrogenases
  • Malate Dehydrogenase (metabolism)
  • Oxidoreductases (metabolism)
  • Trypanosoma cruzi (drug effects, enzymology, growth & development)

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