Connective tissue accumulation in the left coronary artery of young SHR.

Abstract

The left coronary artery of 21-, 28-, and 45-day-old spontaneously hypertensive rats and Wistar-Kyoto rats was analyzed morphometrically to evaluate the structural alterations of the vessel wall during the development of genetically determined hypertension. In 45-day-old rats, hypertension was associated with a significant expansion of the partial volume of collagen and ground substance (119%) within the arterial wall. This change exceeded the concurrent accumulation of elastin (77%) and smooth muscle cell mass (34%). The growth of the muscle compartment was also characterized by a marked increment of rough endoplasmic reticulum (103%). The increase in the mural concentration of fibrous proteins at this early age may be viewed as the initial adverse effect of hypertension on muscular arteries.

• Authors: P Anversa, M Melissari, A Tardini, G Olivetti
• Journal: Hypertension (Dallas, Tex. : 1979) (Hypertension) 1984 Jul-Aug Vol. 6 Issue 4 Pg. 526-9 ISSN: 0194-911X [Print] United States
• PMID: 6746084 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Topics

• Aging
• Animals
• Arteries
• Blood Pressure
• Connective Tissue (metabolism)
• Coronary Vessels (metabolism, pathology, ultrastructure)
• Hypertension (metabolism, pathology)
• Muscle, Smooth, Vascular (ultrastructure)
• Rats
• Rats, Inbred Strains