Pharmacokinetics and tissue localization of doxycycline polyphosphate and doxycycline hydrochloride in the rat.

Abstract	Two doxycycline derivatives Doxycycline polyphosphate and Doxycycline hydrochloride were administered to rats at a dose of 20 mg/kg body weight. Doxycycline tissue levels were determined using a microbiological assay. Only an insignificant fraction of the antibiotics was found to cross the blood brain barrier. Doxycycline was highly concentrated in excretory organs: liver, kidneys and caecum. The high intestinal drug level observed is probably related to the entero-hepatic cycle of this antibiotic. There was a good correlation between serum and heart doxycycline concentration; heart level was about twice that of serum. In lung, antibiotic level was always higher than in serum.
Authors	G Michel, J Mosser, J Olle
Journal	European journal of drug metabolism and pharmacokinetics (Eur J Drug Metab Pharmacokinet) 1984 Apr-Jun Vol. 9 Issue 2 Pg. 149-53 ISSN: 0378-7966 [Print] France
PMID	6745305 (Publication Type: Journal Article)
Chemical References	doxycycline polyphosphate Doxycycline
Topics	Animals Doxycycline (analogs & derivatives, metabolism) Female Kinetics Male Rats Rats, Inbred Strains Tissue Distribution

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!