Disturbance of recent memory function in parkinsonian patients on anticholinergic therapy.

Abstract

Disruption of cholinergic neurotransmission may result in memory impairment. In this study the anticholinergic drug, trihexyphenidyl, at low doses when administered chronically for one month to Parkinson disease patients caused a decrease in performance on recent but not immediate memory tests. Awareness of possible deterioration of memory function of parkinsonian patients on anticholinergic medication is necessary.

• Authors: W C Koller
• Journal: Cortex; a journal devoted to the study of the nervous system and behavior (Cortex) Vol. 20 Issue 2 Pg. 307-11 (Jun 1984) ISSN: 0010-9452 [Print] Italy
• PMID: 6744901 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Trihexyphenidyl

Topics

• Aged
• Humans
• Memory (drug effects)
• Mental Recall (drug effects)
• Paired-Associate Learning (drug effects)
• Parkinson Disease (drug therapy)
• Trihexyphenidyl (adverse effects, therapeutic use)
• Verbal Learning (drug effects)