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Chromosome features of two retinoblastomas.

Abstract
Giemsa-banded chromosomal analysis of two unilateral retinoblastoma tumors from unrelated patients with normal constitutional chromosomes revealed near-diploid karyotypes with multiple structural rearrangements. The two tumors shared aberrations of trisomy 1q, monosomy 16 and 17, and 21p+. Other aberrations were unique to each tumor. One tumor expressed a del(13) and trisomy 6p.
AuthorsM L Workman, S W Soukup
JournalCancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 12 Issue 4 Pg. 365-70 (Aug 1984) ISSN: 0165-4608 [Print] United States
PMID6744228 (Publication Type: Journal Article)
Topics
  • Adult
  • Chromosome Aberrations
  • Chromosome Banding
  • Chromosomes, Human, 1-3
  • Chromosomes, Human, 16-18
  • Chromosomes, Human, 21-22 and Y
  • Eye Neoplasms (genetics)
  • Humans
  • Karyotyping
  • Male
  • Retinoblastoma (genetics)
  • Trisomy

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