Reversible suppression of amygdaloid kindled convulsion following unilateral gabaculine injection into the substantia innominata.

Abstract

Amygdaloid kindled generalized convulsion was reversibly blocked despite continued afterdischarge generation by amygdaloid stimulation for about 60 h following intracerebral administration of gabaculine, a GABA-transaminase inhibitor, into the substantia innominata (SI) ipsilateral to the side of amygdaloid kindling. It is suggested that the SI plays an important role in convulsive seizure generalization of amygdaloid origin.

• Authors: M Okamoto, J A Wada
• Journal: Brain research (Brain Res) Vol. 305 Issue 2 Pg. 389-92 (Jul 09 1984) ISSN: 0006-8993 [Print] Netherlands
• PMID: 6744074 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aminocaproates
• Anticonvulsants
• Cyclohexanecarboxylic Acids
• Muscimol
• gabaculine
• Vigabatrin

Topics

• Action Potentials (drug effects)
• Aminocaproates (pharmacology)
• Amygdala (drug effects)
• Animals
• Anticonvulsants
• Basal Ganglia (drug effects)
• Cyclohexanecarboxylic Acids (pharmacology)
• Female
• Kindling, Neurologic (drug effects)
• Muscimol (pharmacology)
• Rats
• Seizures (prevention & control)
• Substantia Innominata (drug effects)
• Tegmentum Mesencephali (drug effects)
• Vigabatrin