[Effect of 1-(chloromethyl)silatrane on biochemical indices in the tissue of experimental gastric ulcer].

Abstract

It has been demonstrated in rats with experimental gastric ulcer that 1-(chloromethyl) silatrane intensifies the development of granulation-fibrous tissue and favours optimization of the ratio of collagens and glycosaminoglycans, the main connective tissue biopolymers. Furthermore, 1-(chloromethyl) silatrane produces a more pronounced effect on hexosamine-containing glycoproteins in the ulcer tissue as compared with methyluracil and oxyferriscorbon. At the same time, judging by the time course of sialoproteins, the antiulcerous drugs, methyluracil and oxyferriscorbon, are much more effective antiinflammatory agents than 1-(chloromethyl)silatrane.

• Authors: I G Kuznetsov, L I Slutskiĭ, S K Suslova, O A Gol'dberg, M G Voronkov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 97 Issue 6 Pg. 658-60 (Jun 1984) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie 1-(khlormetil)silatrana na biokhimicheskie pokazateli tkani éksperimental'noĭ iazvy zheludka.
• PMID: 6743799 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Ulcer Agents
• Drug Combinations
• Ferric Compounds
• Hexosamines
• Hexoses
• Hexuronic Acids
• Organosilicon Compounds
• Sialic Acids
• 2,3-Diketogulonic Acid
• Tyrosine
• oxyferriscorbone
• Alloxan
• 1-(chloromethyl)silatrane
• Methylthiouracil
• Hydroxyproline
• Silicon

Topics

• 2,3-Diketogulonic Acid (therapeutic use)
• Alloxan (therapeutic use)
• Animals
• Anti-Ulcer Agents (therapeutic use)
• Drug Combinations (therapeutic use)
• Ferric Compounds (therapeutic use)
• Hexosamines (metabolism)
• Hexoses (metabolism)
• Hexuronic Acids (metabolism)
• Hydroxyproline (metabolism)
• Methylthiouracil (therapeutic use)
• Organosilicon Compounds
• Rats
• Sialic Acids (metabolism)
• Silicon (therapeutic use)
• Stomach Ulcer (drug therapy, metabolism)
• Tyrosine (metabolism)