Theophylline: constant-rate infusion predictions.

Abstract

This study was undertaken to evaluate a method of prospectively estimating appropriate aminophylline infusion rates in acutely ill, hospitalized patients with bronchospasm. Steady-state serum theophylline concentrations (Css), clearances (Cl), and half-lives (t1/2) were estimated by the Chiou method using serum concetrantions obtained 1 and 6 h after the start of a constant-rate intravenous aminophylline infusion in 10 male patients averaging 57 years of age. Using an enzyme-multiplied immunoassay (EMIT) system for theophylline analysis, pharmacokinetic estimations were excellent for Css (r = 0.9103, p less than 0.01) and Cl (r = 0.9750, p less than 0.01). The mean estimation errors were 9.4% (range 0.8-21.5) for Css and 12.3% (range 1.3-28.0) for Cl. There was no correlation between patient age and Cl. This method is useful for rapidly individualizing aminophylline therapy in patients with acute bronchospasm.

• Authors: C A Mesquita, H Sahebjami, T Imhoff, J P Thomas, S A Myre
• Journal: Therapeutic drug monitoring (Ther Drug Monit) Vol. 6 Issue 2 Pg. 157-63 ( 1984) ISSN: 0163-4356 [Print] United States
• PMID: 6740734 (Publication Type: Journal Article)

Chemical References

• Aminophylline
• Theophylline

Topics

• Adult
• Aged
• Aminophylline (administration & dosage, metabolism)
• Bronchial Spasm (blood, drug therapy)
• Half-Life
• Humans
• Infusions, Parenteral
• Kinetics
• Male
• Metabolic Clearance Rate
• Middle Aged
• Regression Analysis
• Theophylline (blood, metabolism, therapeutic use)