Efficacy of antifungal agents in the cornea. IV. Amphotericin B methyl ester.

Abstract

Quantitative mycologic techniques were used to evaluate the efficacy of topical amphotericin B methyl ester in two models of yeast infection in rabbit eyes. Doses of 1%, 0.5%, and 0.15% were used in a model of superficial Candida albicans infection. The 1% dose of drug was highly efficacious, abolishing the disease after 2 days of treatment. With doses of 0.5% and 0.15%, decreasing efficacy was observed. Antifungal activity did not deteriorate when 1% prednisolone acetate was administered concomitantly with the 1% dose. In a model of deep stromal infection, the administration of topical 1% amphotericin B methyl ester was highly efficacious when the corneal epithelium was absent. Even in corneas with intact epithelium, a reduced though still significant effect was noted.

• Authors: D M O'Day, W A Ray, W S Head, R D Robinson
• Journal: Investigative ophthalmology & visual science (Invest Ophthalmol Vis Sci) Vol. 25 Issue 7 Pg. 851-4 (Jul 1984) ISSN: 0146-0404 [Print] United States
• PMID: 6735649 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antifungal Agents
• methylamphotericin B
• Amphotericin B
• prednisolone acetate
• Prednisolone

Topics

• Administration, Topical
• Amphotericin B (administration & dosage, analogs & derivatives, therapeutic use)
• Animals
• Antifungal Agents (administration & dosage, therapeutic use)
• Candidiasis (drug therapy)
• Corneal Diseases (drug therapy)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Drug Therapy, Combination
• Prednisolone (administration & dosage, analogs & derivatives)
• Rabbits
• Time Factors