[Augmentation of NK activity in peripheral blood lymphocytes of cancer patients by intermittent GE-132 administration].

Abstract

The natural killer (NK) activity of peripheral blood lymphocytes from 18 cancer patients was studied prior to and after multiple administration of organo-germanium compound (Ge-132). In successive oral administration of Ge-132 at a dose of 1000 mg/day for 10 days, NK-activity of patients was augmented at 3 days, but by 10 days, depression of NK activity was observed in all cases. In intermittent oral administration of Ge-132, however, more than half of the patients with augmented NK activity at day 3 maintained the high activity level at day 10. This result suggests the superiority of intermittent administration of Ge-132 for clinical use.

• Authors: N Tanaka, J Ohida, M Ono, H Yoshiwara, T Beika, A Terasawa, J Yamada, S Morioka, T Mannami, K Orita
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 11 Issue 6 Pg. 1303-6 (Jun 1984) ISSN: 0385-0684 [Print] Japan
• PMID: 6732257 (Publication Type: Journal Article)

Chemical References

• Organometallic Compounds
• Propionates
• Germanium
• propagermanium

Topics

• Colonic Neoplasms (immunology)
• Cytotoxicity, Immunologic
• Germanium (pharmacology)
• Humans
• Killer Cells, Natural (drug effects, immunology)
• Lung Neoplasms (immunology)
• Organometallic Compounds (pharmacology)
• Propionates
• Stomach Neoplasms (immunology)