[Effect of pathologic changes in the urinary epithelium on the absorption of ethoglucide (Epodyl) from the bladder].

Abstract

Studies on the absorption of Ethoglucid from human urinary bladder, utilizing a photometric method to determine Ethoglucid in biological fluids, gave the following results: The intact uroepithelium prevents absorption of interluminal Ethoglucid as well as no significant increase of absorption was seen in the presence of superficial, highly differentiated cancers or inflammatory alterations of the bladder. Urothelial lesions after transurethral resection or infiltrating cancers permit an intercellular diffusion of Ethoglucid from the bladder cavity into the systemic circulation, due to a loss of intercellular gaps between the urothelial elements.

• Authors: G Lunglmayr, C Kratzik, M Mattausch
• Journal: Wiener klinische Wochenschrift (Wien Klin Wochenschr) Vol. 96 Issue 5 Pg. 182-5 (Mar 02 1984) ISSN: 0043-5325 [Print] Austria
• Vernacular Title: Einfluss pathologischer Urothelveränderungen auf die Resorption von Ethoglucid (Epodyl) aus der Harnblase.
• PMID: 6730516 (Publication Type: English Abstract, Journal Article)

Chemical References

• Ethers
• Ethoglucid

Topics

• Absorption
• Epithelium (metabolism)
• Ethers (therapeutic use)
• Ethoglucid (blood, therapeutic use)
• Female
• Humans
• Urinary Bladder (metabolism)
• Urinary Bladder Neoplasms (drug therapy)