Abstract |
Anticonvulsant and convulsant effects of various piperidine dicarboxylic acids have been evaluated following their intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) injection in DBA/2 mice, a strain of mice genetically susceptible to sound-induced seizures. Protection against sound-induced seizures occurred after intraventricular administration of (+/-)cis-2,3- piperidine dicarboxylic acid (0.017-0.045 mumol), (+/-)trans-2,3- piperidine dicarboxylic acid (0.018-0.33 mumol) and (+/-)cis-2,4- piperidine dicarboxylic acid (0.57-1.68 mumol). Protection against sound-induced seizures occurred after intraperitoneal injection of (+/-)cis-2,3- piperidine dicarboxylic acid (0.52-1.8 mmol/kg). Myoclonus or convulsions occurred at various times after the intraventricular injection of cis-2,3-piperidine dicarboxylic acid, trans-2,3-, cis-2,4-, cis-2,5- and cis-2,6-, piperidine dicarboxylic acids, and after the intraperitoneal injection of trans-2,3-piperidine dicarboxylic acid. The latter effect was blocked by pretreatment with 2-amino-7-phosphonoheptanoic acid (0.33 mmol/kg, i.p.) a potent and specific antagonist of excitation induced by N-methyl-D-aspartate. The anticonvulsant action of cis-2,3-piperidine dicarboxylic acid and the convulsant action of trans-2,3-piperidine dicarboxylic acid were associated with predominant antagonist and agonist actions respectively, at receptors preferring N-methyl-D-aspartate.
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Authors | M J Croucher, B S Meldrum, J F Collins |
Journal | Neuropharmacology
(Neuropharmacology)
Vol. 23
Issue 4
Pg. 467-72
(Apr 1984)
ISSN: 0028-3908 [Print] England |
PMID | 6728132
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Pipecolic Acids
- 2,3-piperidinedicarboxylic acid
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Topics |
- Acoustic Stimulation
- Animals
- Anticonvulsants
(administration & dosage, pharmacology, toxicity)
- Chemical Phenomena
- Chemistry
- Female
- Injections, Intraperitoneal
- Injections, Intraventricular
- Male
- Mice
- Mice, Inbred DBA
- Pipecolic Acids
(administration & dosage, pharmacology, toxicity)
- Seizures
(chemically induced, prevention & control)
- Stereoisomerism
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