HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Anticonvulsant and proconvulsant properties of a series of structural isomers of piperidine dicarboxylic acid.

Abstract
Anticonvulsant and convulsant effects of various piperidine dicarboxylic acids have been evaluated following their intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) injection in DBA/2 mice, a strain of mice genetically susceptible to sound-induced seizures. Protection against sound-induced seizures occurred after intraventricular administration of (+/-)cis-2,3-piperidine dicarboxylic acid (0.017-0.045 mumol), (+/-)trans-2,3-piperidine dicarboxylic acid (0.018-0.33 mumol) and (+/-)cis-2,4-piperidine dicarboxylic acid (0.57-1.68 mumol). Protection against sound-induced seizures occurred after intraperitoneal injection of (+/-)cis-2,3-piperidine dicarboxylic acid (0.52-1.8 mmol/kg). Myoclonus or convulsions occurred at various times after the intraventricular injection of cis-2,3-piperidine dicarboxylic acid, trans-2,3-, cis-2,4-, cis-2,5- and cis-2,6-, piperidine dicarboxylic acids, and after the intraperitoneal injection of trans-2,3-piperidine dicarboxylic acid. The latter effect was blocked by pretreatment with 2-amino-7-phosphonoheptanoic acid (0.33 mmol/kg, i.p.) a potent and specific antagonist of excitation induced by N-methyl-D-aspartate. The anticonvulsant action of cis-2,3-piperidine dicarboxylic acid and the convulsant action of trans-2,3-piperidine dicarboxylic acid were associated with predominant antagonist and agonist actions respectively, at receptors preferring N-methyl-D-aspartate.
AuthorsM J Croucher, B S Meldrum, J F Collins
JournalNeuropharmacology (Neuropharmacology) Vol. 23 Issue 4 Pg. 467-72 (Apr 1984) ISSN: 0028-3908 [Print] England
PMID6728132 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Pipecolic Acids
  • 2,3-piperidinedicarboxylic acid
Topics
  • Acoustic Stimulation
  • Animals
  • Anticonvulsants (administration & dosage, pharmacology, toxicity)
  • Chemical Phenomena
  • Chemistry
  • Female
  • Injections, Intraperitoneal
  • Injections, Intraventricular
  • Male
  • Mice
  • Mice, Inbred DBA
  • Pipecolic Acids (administration & dosage, pharmacology, toxicity)
  • Seizures (chemically induced, prevention & control)
  • Stereoisomerism

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: