Abstract |
Trichlorfon ( metrifonate) was given intermittently to 37 schoolboys with urinary schistosomiasis living in a hyperendemic area of the Sudan. Patients were followed up for three years. Initially, 10 mg of trichlorfon/kg of body weight was administered; this dosage was repeated 14 days and 16 months later. Patients still excreting eggs after 24 months received a fourth dose. At month 24, 61% and at month 36, 56% of the patients had no detectable egg excretion; the others showed severe reduction of egg output. The number of ova excreted was always paralleled by a combined scale of hematuria, leukocyturia , and proteinuria, as assessed by urine analysis reagent strips. Quantitative urine analysis at month 36 revealed pathological findings in only eight individuals. Thus, trichlorfon given three or four times in a dose of 10 mg/kg of body weight spaced over a period of two years was highly effective in reducing parasite load and disease in children living under hyperendemic conditions.
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Authors | E Doehring, H Feldmeier, A A Dafalla, J H Ehrich, U Vester, U Poggensee |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 149
Issue 4
Pg. 615-20
(Apr 1984)
ISSN: 0022-1899 [Print] United States |
PMID | 6725993
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Child
- Drug Administration Schedule
- Hematocrit
- Hematuria
(drug therapy)
- Humans
- Leukocytes
- Male
- Parasite Egg Count
- Proteinuria
(drug therapy)
- Schistosoma haematobium
- Schistosomiasis
(drug therapy, urine)
- Trichlorfon
(administration & dosage)
- Urinary Tract Infections
(drug therapy, urine)
- Urine
(cytology)
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