A comparative study of spiramycin and erythromycin in acute tonsillo-pharyngitis.

Abstract

In a clinical and bacteriological study of 42 patients with acute tonsillo-pharyngitis or chronic tonsillo-pharyngitis with acute exacerbation, patients were allocated at random to receive either a 3-day course of spiramycin or a 5-day course of erythromycin, both antibiotics being given in a dosage of 500 mg 3-times daily. The median time to disappearance of patient complaints such as fever, difficulty in swallowing, sore throat, cough and mucus was 3 days in each group and there was a significant reduction from pre-treatment to normal levels in total white cell count and erythrocyte sedimentation rate after treatment. Although more patients were considered to have shown a good clinical response to spiramycin, the difference was not statistically significant. From a bacteriological point of view, however, treatment with the regimen used was considered a failure in all cases in that neither antibiotic completely eradicated the pathogens identified at the start of treatment even though, with 3 exceptions, all of the micro-organisms were shown to be sensitive to the antibiotics before and after treatment. Few side-effects were reported in either group.

• Authors: Zulkifli, H Fachri, S Efiaty, M H Yunisaf, N Iskandar
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 8 Issue 10 Pg. 708-13 ( 1984) ISSN: 0300-7995 [Print] England
• PMID: 6723348 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Leucomycins
• Erythromycin

Topics

• Acute Disease
• Adolescent
• Adult
• Bacteria (isolation & purification)
• Erythromycin (adverse effects, therapeutic use)
• Female
• Humans
• Leucomycins (adverse effects, therapeutic use)
• Male
• Middle Aged
• Pharyngitis (drug therapy)
• Tonsillitis (drug therapy)