1,3-Di(4- sulfamoylphenyl )-triazene (
DSPT ), synthesized from two equivalents of sulfanylamide and one equivalent of
sodium nitrite, induced specific types of
tumors (lymphoreticular
neoplasias) in the offspring, when it was given orally to pregnant mice on Days 13-18.
Tumor incidences were 6.1, 20.0, and 21.7%, when
DSPT was given at 1, 4 and 10% concentration in the diet, respectively, while the control value was 0.8%.
DSPT did not induce lung
tumors, which are commonly induced by mutagenic
carcinogens.
DSPT also produced malformations (
cleft palate, exencephalus , etc.), when given intraperitoneally on Days 9, 10 and 11. Incidence increased with increasing doses of
DSPT , that is, 15.8, 21.1 and 36.7% at doses of 22, 36 and 44 micrograms/g, respectively, while the incidence was 0.3% in the untreated controls.
DSPT was found to be non-mutagenic but weakly clastogenic in Drosophila melanogaster.